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IDH1/2 mutants use NADPH to transform -ketoglutarate (-KG) into D-2-hydroxyglutarate (D-2HG) which can act as an oncometabolite

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Xiong Y, Yang Y, Yang J, Chai H, Li Y, Yang J, et al

For instance, dimerization of GluK2/K5 heterodimers (K D = 77 nM) occurs much more robustly and favorably compared to GluK2 homodimers (K D = 350 nM), contributing to the greater abundance of GluK2/K5 heterotetramers in the brain when compared to GluK2 homotetramers (Zhao et al., 2017)

A., Holton, T., Yuneva, M., Louie, R