The trial enrolled 3,127 participants without diabetes
These compounds block the action of an enzyme, dipeptidyl peptidase-IV, which normally rapidly degrades GLP-1
This explains one of the most common frustrations with GLP-1 therapy
Molecular studies on the mechanisms of action of antipsychotics and antidepressants, and of hypoglycemic drugs used for metabolic disorders, are beginning to show that some key enzymes can regulate aspects of both energy management and psychopathology
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