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[DOI] [PubMed] [Google Scholar] 197.Strain WD, et al

This concern exists independently of semaglutide use

Studies have shown that high doses of PPR (e.g., 10 mg/kg) significantly reduce sperm motility, concentration, and viability in adult male rats, with adverse effects on key reproductive markers and antioxidant enzymes (70, 71)

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Your central nervous system is working overtime to adapt to these new signals, which can manifest as central fatigue, a feeling of exhaustion that isn't relieved by rest