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they are not standardized and are not the same as controlled clinical trial regimens

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Greenleaf frames the physiology bluntly in the course: the body interprets aggressive caloric restriction as stress or famine and will hold on to weight and break down protein, so adequate protein intake is needed to prevent muscle loss during weight loss

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This suggests that increased oxidative stress is an important factor for the reliability of biomarkers indicating neonicotinoid exposure