A phase 2 trial published in the New England Journal of Medicine showed average weight loss of over 24% at 48 weeks, and the first phase 3 results in December 2025 suggested that average weight loss could be around 28 to 29%
GLP-1 medications can lead to significant weight loss, especially when paired with healthy eating and regular physical activity as part of comprehensive lifestyle changes
These drugs mimic a natural hormone that regulates blood sugar and appetite
How Tesofensine works Targets the brain makes food stop giving you a dopamine hit Reduces cravings for sweets and junk without fully suppressing hunger like GLP-1s Does NOT spike blood sugar during fasting Real energy increase dopamine-driven motivation, not jittery stimulant energy Great GLP-1 transition compound for weaning off without falling off track Real-world experience JD's first run felt off and tired gave it a bad rep initially
They must take the medication on an empty stomach
Interestingly, while glycosuria and natriuresis persist, osmotic diuresis typically diminishes with continued SGLT2 inhibitor treatment
