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The M2 loop creates a constricted segment within the pore, which governs ion selectivity, permeation, and channel block, possibly playing the role of a lower gate in the channel (Wollmuth and Sobolevsky, 2004

10.1128/mSphere.01044-20 mSphere 26 ChiuT

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Consulting with your healthcare provider and referring to a Zepbound (tirzepatide) dosing chart together is an essential step in ensuring you are utilizing the medication appropriately to have excellent results while minimizing side effects