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In general, AA is produced through an aerobic fermentation process, whose synthesis route is based on the oxidation of ethanol present in fruits (grapes, apples, and coconuts) and grains (rice and wheat)

doi:10.1016/j.foodchem.2024.140849 zdemir S, Demirta S

Guan, Y.-J

However, in two key phase III clinical trials in lung cancer(SKYSCRAPER-01 and SKYSCRAPER-02), the combination therapy did not demonstrate strong synergistic effects [100]

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doi: 10.4049/JIMMUNOL.2400344 116 FerreiraRCGuoHCoulsonRMRSmythDJPekalskiMLBurrenOSet al