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10.3390/molecules25010188 Molecules 57 Leeman-MarkowskiB.SchachterS

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Some patients develop highly aggressive small-cell neuroendocrine carcinoma, which is often characterized by resistance to ADT, a relative lack of clinical treatment strategies and a high mortality rate (5-year survival rate is only ~10%) (57)

Therefore, there is limited experience on the long-term side effects of ICIs