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470 SGLT2 inhibition is also known to benefit patients with heart failure and a reduced ejection fraction

Second, long-term outcomes are still being studied

5,6 However, persistence appears to be improving

Although the cardiovascular advantages of GLP-1RAs in diabetic patients are well-documented [8], there has been limited evidence to support their effectiveness in reducing CVD risk in individuals who are obese or overweight but do not have diabetes

Conversely, antagonizing amylin receptors leads to an increase in adipose tissue [95]

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