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However, safety is context-dependent

This distinction matters because exogenous GH administration carries a different risk profile than peptide-stimulated endogenous release

Following an acute administration of EtOH (5 g/kg, i.p.), KO animals exhibited 30% and 50% less EtOH and AA accumulation in circulation, respectively, suggesting an increased capacity for liver EtOH and AA metabolism in KO mice

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