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337 Mice that specifically knock out the Nampt gene of adipocytes have serious insulin resistance, which is manifested by an increase in plasma free fatty acid content and a decrease in plasma content of the main insulin-sensitive adipokine, adiponectin

Researchers have commented that the peptide appears to cause increases in mean plasma GH concentrations by 2- to 10-fold [...] and in mean plasma IGF-I concentrations by 1.5- to 3-fold... [2] CJC-1295 has been primarily researched for its potential in mitigating actions frequently associated with cell aging

PMID: 31043597

[6] These analyses are useful, but they are the weakest tier for a two-drug verdict: indirect comparisons inherit every difference between the underlying trials and cannot substitute for a randomised head-to-head