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6.3 Immune dysregulation For decades, immune cells and cytokines have been associated with human hypertension, but recent advances in immunological tools and animal models have allowed detailed examination of their roles in various experimental models

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Lancet Oncol 16(6):619629 Demetri GD et al (2013) Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, phase 3 trial

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Peak plasma concentrations were reported to be in the range of 115 M (Novelli and Rosi 2017

For example, ER stress activates DNA damage inducible transcript 3 (DDIT3, also known as CHOP)- and mitogen-activated protein kinase 8 (MAPK8, also known as JNK)-dependent apoptosis pathways, whereas heat shock protein family A member 5 (HSPA5, also known as BIP) SSG at Cys420/441 modulates ATPase activity and protein folding, paradoxically suppressing apoptosis 49