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Most patients begin noticing reduced appetite and fewer cravings within the first few weeks

But, in patients without diabetes, preliminary studies suggest GLP-1 use could be associated with lower risk, although more research is needed 32

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Along with these studies and several additional meta-analyses, it can be concluded that GLP-1R agonists, especially liraglutide and semaglutide, are successful in inducing substantial weight reduction, are well tolerated, and also show signs of improving obesity-related risk factors [80,81]

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