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Rats treated with TMAO have been shown to increase inflammatory markers and promote early atherosclerosis modifying lipid metabolism and biomarkers

PMID 18492135 Bissett, D

Kraemer, J.S

In vivo, mutant clones expand over a period of months to years, to multi-millimeter sizes competing for the limited space available in homeostatic epithelia 27,28,29,30,31,32

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