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The answer often comes down to peptide vs GLP-1 mechanism

Survival of patients (pts) with microsatellite stable/mismatch repair proficient (MSS/pMMR) metastatic colorectal carcinoma (mCRC) treated with EO4010 + nivolumab (EO/N)

[DOI] [PubMed] [Google Scholar] 19.Marquez-Exposito L., Tejedor-Santamaria L., Valentijn F.A., Tejera-Muoz A., Rayego-Mateos S., Marchant V., Rodrigues-Diez R.R., Rubio-Soto I., Knoppert S.N., Ortiz A., et al

The proportion of Americans who report having used or knowing someone who has used a GLP-1 in the past three months has consistently risen in Axios/Ipsos polling since 2023

So, semaglutide functionally uncouples the feeling of satiety (or fullness) from having eaten, allowing people to eat less and lose weight