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There are also some limitations in this study, such as the relatively small number of patients and lack of samples of patients with a more advanced stage of NSCLC, such as stage IV, since ser/gly metabolism hyperactivation is associated to poor prognostic advanced NSCLC

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161 There is extensive cross-regulation between autophagy and ER stress, 162 and SIRT1 may coordinate the feedback mechanisms between these processes

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The authors GG, AIM, AnM, CM declared that they were an editorial board member of Frontiers at the time of submission

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