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At the expected therapeutic dose of 0.5mg, the discontinuation rate due to side effects was similar to that of the placebo group (32%).In another trial called TIPO-2, which lasted for 14 days, tesofensine was found to reduce the desire to eat and increase feelings of fullness in obese patients

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Etiological Mechanisms of Weight Gain in Patients with PWS Multiple alterations in energy homeostasis are commonly reported in patients with PWS and contribute to the massive weight gain in these patients [24]

National Institute of Health and Care Excellence

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