Pregnant women should be sure to get folate from a supplement to help avoid birth defects, and people with genetic mutations affecting the MTHFR enzyme may benefit from a form of folate known as methylfolate
This allows for higher bioavailability than oral supplements, which are often broken down in the gut before they can be effectively absorbed
GGT is also involved in the transfer of amino acids across cell membranes 103 and metabolism of leukotriene
however, uncontrolled accumulation triggers oxidative stress, leading to lipid peroxidation, protein oxidation, DNA damage, and impairment of photosynthetic and respiratory processes (Mishra et al
In summary, while standard IV doses are usually safe, any severe symptoms should prompt immediate medical attention
Neslihan Gursoy R, Benita S