The human leukocyte antigen ( HLA-Cw6 ) is considered one of the strongest alleles determining the development of this disease (199, 207)
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It is estimated that up to 40% of the population carries at least one variant of the MTHFR gene (such as the C677T polymorphism), which significantly reduces the enzyme's ability to convert dietary folate into its active form, L-5-MTHF
It is unfeasible as a therapy for obesity or diabetes, as patients would essentially need to be tethered to a continuous intravenous infusion
It also serves as a growth-factor-like molecule because it influences the expression of thousands of genes in the body , which may help support cellular regeneration and skin remodeling
Zhang Z, Ma L, Geng H, Bian Y