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Increased activity of these autoinhibitory factors attenuates leptin signaling and is also implicated in leptin resistance [17]

We also proposed to finalize the status indicator and APC assignments for these codes (with their final CPT code numbers) in the CY 2026 OPPS/ASC final rule with comment period

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They are intended to support weight-loss efforts as part of a larger wellness plan that includes diet and exercise.

Hence, its crucial that the therapy is administered by a qualified healthcare professional who can monitor for these risks