While PP1 induces GSK3 activation and decreases nuclear Nrf2 levels, thereby promoting ferroptosis, the presence of ROS upregulates MKLP2, increases GPX4 and GSH levels, and decreases ferroptosis [118, 119]
Mitochondrial fatty acid oxidation is the primary fuel source in heart and skeletal muscle, pointing to the relative importance of this nutrient for proper function in these tissues
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, 5%
No single adverse reaction led to discontinuation in 1% or more of VYVANSE-treated patients