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(2006) 291:E10814
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2 Microvascular (e.g., nephropathy, retinopathy, and neuropathy) and macrovascular (e.g., CV and cerebrovascular disease) complications are associated with considerable morbidity and mortality in people with T2D, as well as a significant cost to the healthcare system
Additionally, GPX3 can interact with GSH and thioredoxin reductase, or with thioredoxin alone, to produce electrons for GSH in the presence of GSH depletion (18), which in turn protects the cells from ROS-induced deoxyribonucleic acid (DNA) and cellular damage (15)