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Advantages and scientific basis of combination therapy The combination of PDE5 inhibitors (PDE5i) and certain nutritional supplements for treating erectile dysfunction (ED) may offer several potential advantages, supported by scientific evidence: Enhanced Efficacy: Some studies suggest that combining PDE5 inhibitors with certain nutritional supplements, such as L-arginine, ginseng, or zinc, may enhance the efficacy of ED treatment

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[DOI] [PMC free article] [PubMed] [Google Scholar] Talvensaari KK, Lanning M, Tapanainen P, Knip M, 1996

However, the findings and conclusions presented in this paper are those of the author(s) and do not necessarily reflect the views of the NIH or the U.S