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Application of BBR in antidiabetic therapy in Chinese herbal compound Coptidis Rhizoma (Huanglian), a core component in traditional Chinese medicine (TCM) formulations for DM, exerts therapeutic effects by targeting the pathogenic Yin deficiency with dryness-heat syndrome (Xiaoke) in TCM theory

On Day 0, each rabbit underwent a surgical procedure to create two full-thickness open wounds

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Specifically, formaldehyde has been demonstrated to suppress the expression of synaptic plasticity-related genes in the hippocampus [81], while cigarette smoke exposure, which includes formaldehyde among its toxic constituents, has been reported to impair insulin signaling and reduce insulin receptor (I-R) expression in peripheral tissues [82]

doi: 10.1038/newbio231232a0

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