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The authors reported a 55.8% reduction in facial wrinkle volume and a 32.8% reduction in wrinkle depth compared with control serum, alongside in vitro evidence that GHK-Cu increased both collagen and elastin production in human dermal fibroblasts at concentrations as low as 0.01 nM [4]

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Notably, the requirement for INTS12-mediated Pol II removal is context dependent, as it is not advantageous during the transcription-coupled response to formaldehyde-induced DNAprotein crosslinks, which rely on a distinct proteasome-dependent degradation pathway