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Besides Alliinase and Allicin also are deactivated by heat, so cooked garlic is less powerful medicinally

Possible action mechanism for curcumin in pre-cancerous lesions based on serum and salivary markers of oxidative stress

Local envenoming by certain snake species known to induce local necrosis (Echis, Cerastes)

J Endocrinol 2023, 258(2)

Users experiencing persistent nausea, vomiting, diarrhea, dehydration, severe abdominal pain, dizziness, inability to maintain adequate fluid intake, or other concerning symptoms should seek medical attention and consult their prescribing clinician promptly

However, high doses such as 600 and even up to 900mg have been used in the literature