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(d) a very long-term follow-up period (till death as end-point), with assessment of both clinical features and serial determinations of the biological markers

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In essence, it combines the benefits of GLP-1 agonist medications (like semaglutide in Ozempic/Wegovy) with the added action of GIP agonism for potentially greater effect [13][14]

36 Our study found that many interventions for DR, including intravitreal injections, panretinal laser photocoagulation, and vitrectomy for DR, were less frequently needed by patients with GLP-1 RA prescriptions compared with those without GLP-1 RA prescriptions