During glucose regulation, activation of these receptors helps improve the function of -cells and protect the pancreas, enhancing insulin secretion and better controlling blood sugar levels
Comparative effectiveness of the sodiumglucose cotransporter 2 inhibitor empagliflozin versus other antihyperglycemics on risk of major adverse kidney events
Many patients report fewer cravings and feel more in control of food decisions after starting treatment
GLP-1 RA use is rising among non-diabetics, raising concerns about misuse
Carcinogenicity concordance between rat and mouse ranged from 36% to 74%
Abbreviations Akt: Protein kinase B BMI: Body mass index cAMP: Cyclic adenosine monophosphate CGRP: Calcitonin gene-related peptide DM: Diabetes mellitus DPP: 4-dipeptidyl peptidase-4 GLP: 1-glucagon-like peptide-1 GLP: 1R-glucagon-like peptide-1 receptor HbA1c: Glycated hemoglobin IGF: Insulin-like growth factor MAPK: Mitogen-activated protein kinase mTOR: Mammalian target of rapamycin NF: B-nuclear factor B PI3K: Phosphoinositide 3-kinase PKA: cAMP-dependent protein kinase SGLT: 2-sodium-glucosecotransporter-2 T2DM: Type 2 diabetes mellitus References Iijima, T., Shibuya, M., Ito, Y., & Terauchi, Y
