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Cognitive function was assessed at the beginning of the study and during follow-up using tests related to word-list learning, digit-symbol substitution, and selective attention

Bartalena, L., Marino, M., Marcocci, C

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Conclusions Progressive WL with a ketogenic VLED induces a transient increase in fasting hunger feelings up to 5% WL (3 weeks), despite no changes in AG and an increase in active GLP-1 AUC

When retatrutide continuously activates GLP-1 receptors on sensory neurons, those neurons can become "trained" to fire more easily, lowering the threshold for what triggers a sensory response