You should contact your GP if: You have been found to have elevated B12 levels on blood tests, particularly if levels exceed 1000 ng/L (approximately 740 pmol/L, though laboratory reference ranges vary) and you are not taking high-dose supplements You develop new symptoms after starting B12 supplementation, including persistent skin rashes, significant gastrointestinal disturbance, or unexplained symptoms You have underlying liver disease, kidney problems, or blood disorders and are considering B12 supplementation You are taking B12 supplements without medical supervision and have not had your levels checked, particularly if taking doses exceeding 2000 micrograms daily You experience symptoms that might indicate underlying disease, such as unexplained weight loss, persistent fatigue, jaundice, or abdominal swelling Call 999 or go to A&E if you develop severe allergic reactions following B12 injections, including difficulty breathing, facial swelling, or widespread rash, as these may indicate anaphylaxis, though this is extremely rare
Dosage recommendations may vary based on the form of BPC 157 and your specific health goals: Injectable BPC 157: If you are using the injectable form, follow the dosage instructions provided by your healthcare provider
During the early escalation phase, when doses are 1 to 4mg weekly, many researchers notice that effects feel strongest in the first 3 to 4 days after injection and diminish toward the end of the week
Nephrol Dial Transplant 32(6):924936
The authors acknowledged that the study was short and also did not include a placebo arm, because providing the placebo form of sublingual vitamin B12 was very difficult
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