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Gao L, Lee BW, Chawla M, Kim J, Huo L, Du L, et al

This is where clinical pharmacological options diverge in mechanism and cost structure

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No impact on bone fractures : If osteoporosis is a concern, the GLP-1 receptor agonists were shown not to increase fracture rates.[ref] Benefits for CVD : In a huge cardiovascular disease study, GLP-1 RAs were shown to be associated with a lower risk of heart attacks and strokes.[ref] Works best with Exercise: A randomized clinical trial found that GLP-1 RAs work best for weight loss when combined with exercise

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