It delays stomach emptying, making you feel full for longer periods after meals, and sends signals to the brain to decrease hunger and food consumption
Treatment usually begins with a lower dose to help your body adjust comfortably
GIP receptors (GIPRs) are highly enriched in oligodendrocytes within the hypothalamic median eminence, and activation of these GIPRs regulates oligodendrocyte survival and myelin plasticity - this process enhances the entry of GLP-1R agonists into the brain via two key pathways: upregulating vascular endothelial growth factor A (VEGF-A) to increase blood-brain barrier permeability and facilitating GLP-1R agonist traversal of myelinated neuronal axons to target hypothalamic nuclei involved in energy homeostasis, including the ARC and PVN [81]
Diabetologia 61 , 21082117 (2018)
van Bloemendaal L, Veltman DJ, ten Kulve JS, Groot PFC, Ruh HG, Barkhof F, et al
In laboratory settings, the activation of the Glucagon receptor is hypothesized to increase energy expenditure and improve mitochondrial function