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The KCNJ11 encoded protein forms the core of the KATP channel and is called Kir6.2

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Interleukin 10 prevents necrosis in murine experimental acute pancreatitis

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However, recurrent bouts of such inflammation and the toxic milieu that ensues, are thought to produce cumulative damage to myelin, oligodendrocytes and neurons, leading to progressive degeneration, atrophy and increasing disability, exacerbated by failure of myelin repair