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Davis theorized that attaching PEG to proteins or small molecules would make them less detectable by the immune system, thereby reducing immune responses while extending their circulation and functional lifespan (121)

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Concurrently, galangin upregulated the expression of heat shock protein 70 (HSP70), B-cell lymphoma-2 (Bcl-2), and tight junction proteins such as claudin-1 and occludin, resulting in reduced mucosal inflammation and improved structural integrity

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