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Epidemiological studies show reciprocal associations between migraine and risk factors like depression, anxiety, and obesity, suggesting shared genetic and physiological pathways involving inflammation and hormonal changes [16,24]

The same year John Edkins, an English physician and physiologist based at St Bartholomew's Hospital in London, found a second gastrointestinal hormone which he named 'gastrin' (Modlin, Kidd, Marks

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