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J Clin Endocrinol Metab 98(4):E664E671

Flushing fluid into your rectum can help to loosen hard stool

Last Published 05.01.2026 Effective Date: 05.01.2026 This policy addresses drug products used as medical therapies for enzyme deficiency

10.1016/j.mvr.2020.104059 14 ChenW.JadhavV.TangJ.ZhangJ

A study that looked at 0.5-1mg/kg/day leucovorin in patients with cerebral folate deficiency (and related neurological symptoms) found that 90% of those supplemented achieved normal 5-methyltetrahydrofolate cerebral spinal fluid concentrations