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With advancing age, structural and functional perturbations within this organelle interaction network lead to convergent pathological outcomes, including impaired energy supply, excessive ROS accumulation, Ca 2+ signaling imbalance, and defective autophagy and quality control

There were other more complicated arms of the trial where they looked at the combination of imlunestrant and abemaciclib in patients who had progressed on CDK4/6 inhibitors in the second line

It is transmitted as an autosomal dominant trait (83,112,113), although most identified cases represent de novo mutations (114)

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This specialized form of GR is encoded by the same gene as cytosolic GR but contains a mitochondrial targeting sequence that directs it to this organelle