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By Lauren Lund, APRN-CNP Reviewed by Laurianne Scott, DO Last Updated: 01/26/2025 In recent years, GLP-1 (glucagon-like peptide-1) medications have garnered significant attention for their effectiveness in helping individuals with weight loss

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commonly prescribed off-label for weight loss Semaglutide has been in clinical use since 2017 and carries the longest real-world safety track record of any GLP-1 medication currently available

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The selection criteria emerging from these global studies are largely structured around specific Body Mass Index (BMI) thresholds and the presence of established cardiometabolic risk factors