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Because semaglutide is not metabolised through the same liver enzyme pathways as cannabinoids, a direct metabolic interaction is unlikely

Vitamin B12 deficiency is common among many, particularly in older people

doi: 10.1074/jbc.M116.721936 82 BrownCWAmanteJJChhoyPElaimyALLiuHZhuLJet al

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(12, 13) By improving glycemic control, enhancing insulin sensitivity, and reducing adiposity, GLP-1 therapies may decrease bone marrow adipose tissue (BMAT) formation and mitigate the harmful effects of hyperglycemia on bone quality

2010 in J Clin Endocrinol Metab pooled the original Phase 3 with the confirmatory NCT00435136 (combined n = 816) and reported sustained visceral-adipose-tissue reduction over 52 weeks alongside broadly stable glucose parameters [7]