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This has been a challenging problem to address since most often the stimulating current creates enough noise that in vivo recording of the responses at the stimulation site are masked
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In animal studies, administration of dexamethasone caused a reduction of GLP-1 secretion from the intestinal L cells [80] and also decreased the circulating levels of this peptide, which led to glucose intolerance and peripheral insulin resistance in rats [81]
The MOTS-C dosage chart outlines the protocols used in preclinical research, though it is critical to note that MOTS-C is still in the preclinical phase for therapeutic use
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