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NICE NG28 and the MHRA advise considering B12 monitoring in long-term metformin users who have symptoms or risk factors for deficiency, as metformin can impair B12 absorption in the terminal ileum

Dosage and Administration: For Cattle, Horses, Swine, and Sheep: Cattle and Horses: 10 - 25 mL Calves and Foals: 5 - 12 mL Swine: 2.5 - 10 mL per animal Piglets, Lambs, and Kids: 1 - 2.5 mL For Dogs and Cats: Dogs: 0.5 - 5 mL Cats: 0.5 - 2.5 mL Precautions: 1.Use caution when administering to pregnant or lactating animals

The body absorbs the amount it needs and disposes of the rest

in models, associated with adipose fat oxidation