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The epigenome drifts significantly with age, silencing genes associated with repair and activating genes associated with inflammation and dysfunction

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[DOI] [PMC free article] [PubMed] [Google Scholar] (96).Dipasquale M

Most importantly, they demonstrate efficacy against schistosome infections in mice, meeting the criteria for lead progression indicated by WHO, and outperform the previously reported efficacy of praziquantel against juvenile worms 13

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