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1.1 GLP-1 RAs: mechanisms and current medications GLP-1, an incretin hormone secreted by intestinal L-cells, plays a crucial role in postprandial metabolic homeostasis ( However, native GLP-1 is rapidly degraded by dipeptidyl peptidase-4 (DPP-4) ( 1.2 GLP-1 RAs and weight loss GLP-1 RAs exert weight-reduction effects by both slowing gut transit and directly activating anorexigenic neural circuits

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The Wegovy pill has a starting dose of 1.5mg, escalating to 4mg, 9mg and 25mg with a minimum duration of one month at each dose level