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GLP-1R biased signalling also occurs in WT receptors following activation with modified peptide agonists (59)

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In patients with T2DM, insulin concentrations are often already supranormal, and treatment with exogenous insulin does not appear to increase protein synthesis, reduce muscle protein breakdown or improve mitochondrial function [170,171,172]

[DOI] [PMC free article] [PubMed] [Google Scholar] 10.Sikiric P., Rucman R., Turkovic B., Sever M., Klicek R., Radic B., Drmic D., Stupnisek M., Misic M., Vuletic L.B., et al