& Cani, P
In summary, GLP-1R on -cells is activated and promotes growth inhibitory hormone secretion, creating a multilayered inhibitory mechanism that effectively reduces glucagon secretion, and in turn lowers blood glucose levels
Furthermore, Ozempic is primarily used for glycemic control in diabetes patients, while Wegovy targets weight management by reducing hunger and enhancing satiety through activation of GLP-1 receptors [52]
In addition, recent studies suggest that GLP-1s may be linked with a rare yet serious condition called nonarteritic anterior ischemic optic neuropathy (NAION)
Further understanding the systemic actions of each hormone in isolation or combination with others and their interactions with their respective receptors will likely enable a better understanding of the processes by which humans maintain metabolic homeostasis under healthy conditions and how these are altered during disease, which will then likely yield more effective new therapeutic options for metabolic diseases such as diabetes and obesity
Stress & Sleep Management: DUTCH testing and advice to improve sleep quality and reduce stress, supporting long-term weight management
