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As with all insulins, the glucose lowering effect time course of LANTUS may vary in different patients or at different times in the same patient and depends on many conditions, including the area of injection as well as the injection site blood supply and temperature [see Clinical Pharmacology (12.2)]

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Although this is a necessary first step in biomedical development, it is also a sign that R&D for these conditions operates in a somewhat rigged race, starting off with and slowed down by a lack of funding and available medical knowledge from the outset