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Avelar-Freitas BA, Almeida VG, Pinto MC, Mourao FA, Massensini AR, Martins-Filho OA et al
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Archived from the original on July 16, 2015
In mouse cells, ARRB2 dampens insulin secretion by partially uncoupling cyclic AMP (cAMP)/protein kinase A (PKA) signaling at physiological doses of GLP-1, whereas at pharmacological doses, the activation of extracellular signal-related kinase (ERK)/cAMP-responsive element-binding protein (CREB) requires ARRB2
Mice were treated subcutaneously at the indicated doses with 5 l per g body weight of either Vehicle, Lani (CAS: 927961-18-0, MedChemExpress), semaglutide, GLP-1Lani, GLP-1Tesa, GLP-1GIP, GLP-1GIPTesa, GLP-1GIPLani, or co-administration of either GLP-1GIP plus Lani or GLP-1Lani plus acyl-GIP (Extended Data Fig
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