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Most scientific data come from clinical research and small clinical trials
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Mechanistically, this was attributed to the inhibition of pyroptosis, evidenced by the downregulation of NLRP3, Caspase-1, IL-1, and IL-18 via the PI3K/AKT/NF-B pathway, ultimately mitigating podocyte injury and ameliorating renal pathology ( Acteosides anti-fibrotic effects on the kidney are shown in Figure 1