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Common side effects during the adjustment period (typically the first 24 weeks): Mild nausea usually less intense than when first starting a GLP-1 medication Changes in appetite (some patients notice less appetite suppression early on at the starting 0.25 mg dose) Mild stomach discomfort, bloating, or constipation Injection site reactions Side effects that are less likely during the switch (compared to first-time GLP-1 use), but still possible: Significant vomiting less common given prior GLP-1 exposure, but possible Hypoglycemia particularly relevant for type 2 diabetes patients on insulin or sulfonylureas

The risks of arrhythmias and their subtypes in published high-quality CVOTs of GLP-1RA drug therapy in patients with type 2 diabetes up to March 1, 2022, were therefore extracted, based on this, we also conducted a systematic review and meta-analysis

This feeling typically intensifies over the first 35 days as the medication reaches steady-state levels in your bloodstream

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