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The GLP-1R is part of the glucagon family of receptors, including the glucose-dependent insulinotropic polypeptide receptor (GIPR) (5), the glucagon receptor (GCGR) (12), and the glucagon-like peptide-2 receptor (GLP-2R) (13), which are class B1/secretin-like G protein-coupled receptors (GPCRs) with a typical structure of seven transmembrane domains (7-TMD), a C-terminal tail, and a large N-terminal extracellular domain (ECD) important for peptide agonist binding (14)

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Death of dopaminergic neurons in the substantia nigra pars compacta and changes in striatal nuclei in patients with Parkinsons disease have been correlated with remarkable changes in structures involved with insulin signaling (Fiory et al., 2019)

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